THE HUMAN BRAIN MICROENVIRONMENT OF PRIMARY CNS LYMPHOMA: HUMAN PLURIPOTENT STEM CELLS‐DERIVED BRAIN MODELS

The brain microenvironment deeply differs from the of any other organ. is, in fact, characterized by distinct metabolic conditions and immune environment, it is composed unique cell types such as neurons cells glia, like astrocytes microglia. Increasing evidence suggests that plays an important role pathogenesis tumors metastases. However, how human niche interacts with eventually remodeled primary central nervous system diffuse large B-cell lymphoma (PCNSL) still a matter investigation. recent advance pluripotent stem (hPSC)-based technologies offers opportunity to virtually derive type body organ-specific organoids. hPSC-derived organoids are self-assembled 3D structures lineage-specific faithfully recapitulate some aspects vivo tissue. We have now developed organoid model high cellular diversity maturation, which allows study PCNSL adaption growth microenvironment. Keyword: Microenvironment, Aggressive non Hodgkin lymphoma, Experimental Therapeutics - No conflicts interests pertinent abstract.